Human Dedicator of Cytokinesis Protein 2 (DOCK2) ELISA Kit | DOCK2 elisa kit
Human Dedicator of Cytokinesis Protein 2 (DOCK2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Uniprot Description
DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cytoskeleton; cytosol; extracellular exosome; extracellular region; membrane
Molecular Function: GTPase activator activity; protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process: actin cytoskeleton organization; alpha-beta T cell proliferation; chemotaxis; establishment of T cell polarity; formation of immunological synapse; lipid raft polarization; macropinocytosis; myeloid dendritic cell activation involved in immune response; negative thymic T cell selection; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of phagocytosis; positive thymic T cell selection; regulation of defense response to virus by virus; small GTPase mediated signal transduction
Disease: Immunodeficiency 40
Research Articles on DOCK2
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Product Notes
The Human DOCK2 dock2 (Catalog #AAA9908378) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9908378 ELISA Kit recognizes Human DOCK2. It is sometimes possible for the material contained within the vial of "Dedicator of Cytokinesis Protein 2 (DOCK2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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