Human CECR1 ELISA Kit | CECR1 elisa kit

Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1) ELISA Kit

Cat. Num. AAA2515808

• Reactivity: Human
• Synonyms: CECR1; Human CECR1 (Cat Eye Syndrome Chromosome Region; Candidate 1) ELISA Kit; CECR1 elisa kit

• Reactivity: Human
• Specificity: This kit recognizes natural and recombinantHumanCECR1. No significant cross-reactivity or interference between HumanCECR1 and analogues was observed.
• Sequence Length: 511

• Samples: Serum, Plasma, Biological Fluids
• Assay Type: Sandwich
• Detection Range: 0.313-20ng/mL
• Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL
• Preparation and Storage: Store at 4 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CECR1 elisa kit

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanCECR1concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CECR1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CECR1and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CECR1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CECR1.You can calculate the concentration of CECR1in the samples by comparing the OD of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 47678365
• UniProt Accession #: Q9NZK5; Q6ICF1; Q86UB6; Q8NCJ2; Q96K41; A8K9H4
• Molecular Weight: 30,668 Da
• NCBI Official Full Name: CECR1
• UniProt Protein Name: Adenosine deaminase CECR1
• Protein Family: Adenosine deaminase
• UniProt Gene Name: CECR1
• UniProt Synonym Gene Names: ADA2; ADGF; IDGFL
• UniProt Entry Name: CECR1_HUMAN

Uniprot Description

CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.4; Hydrolase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: extracellular space; cytosol

Molecular Function: heparin binding; adenosine deaminase activity; proteoglycan binding; protein homodimerization activity; growth factor activity; zinc ion binding; adenosine receptor binding

Biological Process: adenosine catabolic process; multicellular organismal development; hypoxanthine salvage; inosine biosynthetic process

Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome