Human CDK5 regulatory subunit associated protein 2 (CDK5RAP2) ELISA Kit | CDK5RAP2 elisa kit
Human CDK5 regulatory subunit associated protein 2 (CDK5RAP2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
CDK5RAP2: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Defects in CDK5RAP2 are the cause of microcephaly primary type 3 (MCPH3). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: spindle pole; Golgi apparatus; centrosome; microtubule; pericentriolar material; cytoskeleton; perinuclear region of cytoplasm; cytoplasm; cytosol; cell junction
Molecular Function: tubulin binding; calmodulin binding; protein binding; microtubule binding; protein kinase binding
Biological Process: regulation of neuron differentiation; organelle organization and biogenesis; positive regulation of transcription, DNA-dependent; microtubule cytoskeleton organization and biogenesis; negative regulation of centriole replication; chromosome segregation; negative regulation of neuron differentiation; establishment of mitotic spindle orientation; neurogenesis; centrosome organization and biogenesis; brain development; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule bundle formation
Disease: Microcephaly 3, Primary, Autosomal Recessive
Research Articles on CDK5RAP2
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Product Notes
The Human CDK5RAP2 cdk5rap2 (Catalog #AAA7231853) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7231853 ELISA Kit recognizes Human CDK5RAP2. It is sometimes possible for the material contained within the vial of "CDK5 regulatory subunit associated protein 2 (CDK5RAP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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