Human Cardiotrophin Like Cytokine Factor 1 (CLCF1) ELISA Kit | CLCF1 elisa kit

Human Cardiotrophin Like Cytokine Factor 1 (CLCF1) ELISA Kit

Cat. Num. AAA453461

• Gene Names: CLCF1; CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
• Reactivity: Human
• Synonyms: Cardiotrophin Like Cytokine Factor 1 (CLCF1); Human Cardiotrophin Like Cytokine Factor 1 (CLCF1) ELISA Kit; CLC; NR6; BSF3; CISS2; NNT1; Novel Neurotrophin-1; B Cell-Stimulating Factor-3; CLCF1 elisa kit

• Reactivity: Human
• Sequence Length: 215

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 31.25-2000pg/mL
• Sensitivity: 13.9pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 261245022
• NCBI GeneID: 23529
• NCBI Accession #: NP_001159684.1
• NCBI GenBank Nucleotide #: NM_001166212.1
• UniProt Accession #: Q9UBD9; Q6NZA4; B4DNT4
• Molecular Weight: 24,087 Da
• NCBI Official Full Name: cardiotrophin-like cytokine factor 1 isoform 2
• NCBI Official Synonym Full Names: cardiotrophin-like cytokine factor 1
• NCBI Official Symbol: CLCF1
• NCBI Official Synonym Symbols: CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
• NCBI Protein Information: cardiotrophin-like cytokine factor 1
• UniProt Protein Name: Cardiotrophin-like cytokine factor 1
• Protein Family: Cardiotrophin-like cytokine factor
• UniProt Gene Name: CLCF1
• UniProt Synonym Gene Names: BSF3; CLC; NNT1; BSF-3; NNT-1

NCBI Description

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Uniprot Description

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.