Human Bcl11A ELISA Kit | BCL11A elisa kit

Human B-Cell Lymphoma 11A (Bcl11A) ELISA Kit

Cat. Num. AAA2533302

• Gene Names: BCL11A; EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL
• Reactivity: Human
• Synonyms: Bcl11A; Human B-Cell Lymphoma 11A (Bcl11A) ELISA Kit; BCL11A elisa kit

• Reactivity: Human
• Specificity: This kit recognizes natural and recombinantHumanBcl11A. No significant cross-reactivity or interference between HumanBcl11A and analogues was observed.
• Sequence Length: 243

• Samples: Serum, Plasma, Biological Fluids
• Assay Type: Sandwich
• Detection Range: 0.625-40ng/mL
• Sensitivity: Min: 0.375ng/mL; Max: 40ng/mL
• Intra-assay Precision: Intra -assay Precision (Precision within an assay): 3 samples with low, middle and high level Human Bcl11A were tested 20times on one plate, respectively.
• Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Human Bcl11A were tested on 3 different plates, 20replicates in each plate.
• Preparation and Storage: Store at 4 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for BCL11A elisa kit

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanBcl11Aconcentrations in serum, plasma and other biological fluids.

NCBI and Uniprot Product Information

• NCBI GI #: 20336313
• NCBI GeneID: 53335
• NCBI Accession #: NP_612569.1
• NCBI GenBank Nucleotide #: NM_138559.1
• Molecular Weight: 87,554 Da
• NCBI Official Full Name: B-cell lymphoma/leukemia 11A isoform 3
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 11A
• NCBI Official Symbol: BCL11A
• NCBI Official Synonym Symbols: EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL
• NCBI Protein Information: B-cell lymphoma/leukemia 11A
• UniProt Protein Name: B-cell lymphoma/leukemia 11A
• Protein Family: B-cell lymphoma/leukemia
• UniProt Gene Name: BCL11A
• UniProt Synonym Gene Names: CTIP1; EVI9; KIAA1809; ZNF856; BCL-11A; EVI-9
• UniProt Entry Name: BC11A_HUMAN

NCBI Description

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity

Biological Process: B cell differentiation; negative regulation of axon extension; negative regulation of collateral sprouting; negative regulation of protein homooligomerization; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of dendrite development; signal transduction; T cell differentiation; transcription from RNA polymerase II promoter