Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Amiloride-sensitive sodium channel subunit gamma (SCNN1G) Standard Curve.)
Human Amiloride-Sensitive Sodium Channel Subunit gamma (SCNN1G) ELISA Kit | SCNN1G elisa kit
Human Amiloride-Sensitive Sodium Channel Subunit gamma (SCNN1G) ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Amiloride-sensitive sodium channel subunit gamma (SCNN1G) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Amiloride-sensitive sodium channel subunit gamma (SCNN1G) Standard Curve.)
NCBI and Uniprot Product Information
NCBI Description
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Uniprot Description
ENaC-gamma: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
Protein type: Channel, sodium; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p12
Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding; sodium channel activity
Biological Process: sensory perception of taste; response to stimulus; sodium ion transport; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Pseudohypoaldosteronism, Type I, Autosomal Recessive; Liddle Syndrome
Research Articles on SCNN1G
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Product Notes
The Human SCNN1G scnn1g (Catalog #AAA9714400) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714400 ELISA Kit recognizes Human SCNN1G. It is sometimes possible for the material contained within the vial of "Amiloride-Sensitive Sodium Channel Subunit gamma (SCNN1G), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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