Human Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) CLIA Kit | PDCD1LG1 clia kit

Human Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) CLIA Kit

Cat. Num. AAA2025341

• Gene Names: PDCD1LG2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
• Reactivity: Human
• Synonyms: Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1); Human Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) CLIA Kit; CD274; PDL1; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1-LG1; Programed Death Ligand 1; PDCD1LG1 clia kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Programmed Cell Death Protein 1 Ligand 1 (PDL1).; No significant cross-reactivity or interference between Programmed Cell Death Protein 1 Ligand 1 (PDL1) and analogues was observed.
• Sequence Length: 273

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma, Tissue homogenates and Other Biological Fluids
• Detection Range: 27.4-20,000pg/mL
• Sensitivity: < 11.5pg/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Programmed Cell Death Protein 1 Ligand 1 (PDL1) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Programmed Cell Death Protein 1 Ligand 1 (PDL1) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PDCD1LG1 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Programmed Cell Death Protein 1 Ligand 1 (PDL1). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Programmed Cell Death Protein 1 Ligand 1 (PDL1). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Programmed Cell Death Protein 1 Ligand 1 (PDL1) level in the sample or standard.;

Product Categories/Family for PDCD1LG1 clia kit

Signal transduction; Tumor immunity; Infection immunity; Immune molecule; Autoimmunity

NCBI and Uniprot Product Information

• NCBI GI #: 190014605
• NCBI GeneID: 80380
• NCBI Accession #: NP_079515.2
• NCBI GenBank Nucleotide #: NM_025239.3
• Molecular Weight: 20,745 Da
• NCBI Official Full Name: programmed cell death 1 ligand 2
• NCBI Official Synonym Full Names: programmed cell death 1 ligand 2
• NCBI Official Symbol: PDCD1LG2
• NCBI Official Synonym Symbols: B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
• NCBI Protein Information: programmed cell death 1 ligand 2
• UniProt Protein Name: Programmed cell death 1 ligand 2
• UniProt Gene Name: PDCD1LG2
• UniProt Synonym Gene Names: B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
• UniProt Entry Name: PD1L2_HUMAN

Uniprot Description

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: plasma membrane; integral to membrane; endomembrane system

Biological Process: negative regulation of interleukin-10 production; negative regulation of interferon-gamma production; negative regulation of activated T cell proliferation; T cell costimulation; immune response; positive regulation of T cell proliferation