SPRTN blocking peptide
SPRTN Peptide - middle region
Gene Names
SPRTN; DVC1; PRO4323; spartan; C1orf124
Reactivity
Human
Applications
Western Blot
Synonyms
SPRTN; SPRTN Peptide - middle region; SPRTN blocking peptide
Reactivity
Human
Form/Format
Lyophilized powder
Sequence
ATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLA
Sequence Length
489
Applicable Applications for SPRTN blocking peptide
Western Blot (WB)
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Related Product Information for SPRTN blocking peptide
This is a synthetic peptide designed for use in combination with anti-SPRTN Antibody, made
Target Description: SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Target Description: SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Product Categories/Family for SPRTN blocking peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
55kDa
NCBI Official Full Name
sprT-like domain-containing protein Spartan isoform a
NCBI Official Synonym Full Names
SprT-like N-terminal domain
NCBI Official Symbol
SPRTN
NCBI Official Synonym Symbols
DVC1; PRO4323; spartan; C1orf124
NCBI Protein Information
sprT-like domain-containing protein Spartan
UniProt Protein Name
SprT-like domain-containing protein Spartan
UniProt Gene Name
SPRTN
UniProt Synonym Gene Names
C1orf124; DVC1; UNQ1880/PRO4323; DVC1; Spartan
UniProt Entry Name
SPRTN_HUMAN
NCBI Description
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Research Articles on SPRTN
Similar Products
Product Notes
The SPRTN sprtn (Catalog #AAA3242926) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The SPRTN Peptide - middle region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPRTN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the SPRTN sprtn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ATNREPSAHD YWWAEHQKTC GGTYIKIKEP ENYSKKGKGK AKLGKEPVLA. It is sometimes possible for the material contained within the vial of "SPRTN, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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