RGS14 blocking peptide
RGS14 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
RGS14: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cell junction; centrosome; cytoplasm; dendrite; dendritic spine; microtubule; nuclear body; nucleus; plasma membrane; PML body; postsynaptic density; postsynaptic membrane; spindle; spindle pole
Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase activating protein binding; GTPase activator activity; microtubule binding; protein binding; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity
Biological Process: cell division; chromosome segregation; learning; long-term memory; mitosis; negative regulation of MAP kinase activity; negative regulation of synaptic plasticity; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of neurogenesis; regulation of G-protein coupled receptor protein signaling pathway; regulation of transcription in response to stress; response to oxidative stress; spindle organization and biogenesis; visual learning; zygote asymmetric cell division
Research Articles on RGS14
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Product Notes
The RGS14 rgs14 (Catalog #AAA425124) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The RGS14 Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-IGGSLNST TDSAL. It is sometimes possible for the material contained within the vial of "RGS14, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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