RANGRF blocking peptide
RANGRF Peptide - C-terminal region
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Description
RANGRF: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. Belongs to the MOG1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: nucleoplasm; rough endoplasmic reticulum; cytoplasm; plasma membrane; caveola; nucleus
Molecular Function: sodium channel regulator activity; Ran guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; Ran GTPase binding; protein transporter activity
Biological Process: regulation of membrane potential; ER to Golgi vesicle-mediated transport; protein exit from endoplasmic reticulum; regulation of heart rate
Research Articles on RANGRF
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Product Notes
The RANGRF rangrf (Catalog #AAA3244885) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The RANGRF Peptide - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Synthetic peptide located within the following region: TLHQALLRLP QYQTDLLLTF NQPPPDNRSS LGPENLSPAP WSLGDFEQLV. It is sometimes possible for the material contained within the vial of "RANGRF, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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