PAM / PAL Blocking Peptide | PAM blocking peptide
PAM / PAL Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Description
PAM: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 1.14.17.3; Vesicle; EC 4.3.2.5; Lyase; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q14-q21
Cellular Component: cell surface; extracellular space; integral to membrane; membrane; neuron projection; perikaryon; perinuclear region of cytoplasm; plasma membrane; secretory granule membrane; trans-Golgi network
Molecular Function: calcium ion binding; copper ion binding; L-ascorbic acid binding; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; protein binding; protein kinase binding; zinc ion binding
Biological Process: central nervous system development; heart development; lactation; limb development; long-chain fatty acid metabolic process; maternal process involved in pregnancy; odontogenesis; ovulation cycle process; peptide amidation; protein amino acid amidation; protein homooligomerization; regulation of actin cytoskeleton organization and biogenesis; regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to copper ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to hypoxia; response to pH; toxin metabolic process
Research Articles on PAM
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Product Notes
The PAM pam (Catalog #AAA425351) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The PAM / PAL Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-DQEKEDDG SESEE. It is sometimes possible for the material contained within the vial of "PAM / PAL, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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