MAD3 / MXD3 Blocking Peptide | MXD3 blocking peptide

MAD3 / MXD3 Immunizing Peptide

Cat. Num. AAA426373

• Gene Names: MXD3; MYX; MAD3; BHLHC13
• Reactivity: Human,
• Synonyms: MAD3 / MXD3; MAD3 / MXD3 Immunizing Peptide; MXD3; MAD3; MAX dimerization protein 3; MGC2383; hypothetical protein MGC2383; likely ortholog of mouse Max dimerization protein 3; BHLHC13; FLJ35523; MYX; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; MXD3 blocking peptide

• Reactivity: Human,
• Form/Format: 100ug of dried peptide
• Sequence: C-QEHSYSHGGGAWL
• Sequence Length: 206

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13775222
• NCBI GeneID: 83463
• NCBI Accession #: NP_112590.1
• NCBI GenBank Nucleotide #: NM_031300.3
• Molecular Weight: 42,821 Da
• NCBI Official Full Name: max dimerization protein 3 isoform a
• NCBI Official Synonym Full Names: MAX dimerization protein 3
• NCBI Official Symbol: MXD3
• NCBI Official Synonym Symbols: MYX; MAD3; BHLHC13
• NCBI Protein Information: max dimerization protein 3
• UniProt Protein Name: Max dimerization protein 3
• Protein Family: Max dimerization protein
• UniProt Gene Name: MXD3
• UniProt Synonym Gene Names: BHLHC13; MAD3; Max dimerizer 3; bHLHc13
• UniProt Entry Name: MAD3_HUMAN

NCBI Description

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Uniprot Description

MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; protein dimerization activity

Biological Process: negative regulation of transcription, DNA-dependent; transcription, DNA-dependent