anti-Human USP36 Antibody | anti-USP36 antibody

USP36 Antibody

Cat. Num. AAA854953

• Gene Names: USP36; DUB1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: USP36; USP36 Antibody; Ubiquitin carboxyl-terminal hydrolase 36; EC 3.1.2.15; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36; Deubiquitinating enzyme 36; KIAA1453; anti-USP36 antibody

• Reactivity: Human
• Specificity: USP36 antibody detects endogenous levels of total USP36 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 1123

• Applicable Applications for anti-USP36 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human USP36.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using USP36 antibody.)

Product Categories/Family for anti-USP36 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Nagase T., DNA Res. 7:143-150(2000). The MGC Project Team, Genome Res. 14:2121-2127(2004). Ota T., Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 1375383939
• NCBI GeneID: 57602
• UniProt Accession #: Q9P275; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8
• Molecular Weight: 122,908 Da
• NCBI Official Full Name: Ubiquitin carboxyl-terminal hydrolase 36
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 36
• NCBI Official Symbol: USP36
• NCBI Official Synonym Symbols: DUB1
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 36
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 36
• Protein Family: Ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: USP36

NCBI Description

This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

Uniprot Description

Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).