anti-Human RMP Antibody | anti-RMP antibody

RMP Antibody

Cat. Num. AAA8509939

• Gene Names: URI1; RMP; URI; NNX3; C19orf2; PPP1R19
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RMP; RMP Antibody; NNX3; RNA polymerase II subunit 5-mediating protein; RNA polymerase II; subunit 5-mediating protein; RPB5-mediating protein; unconventional prefoldin RPB5 interactor; URI; anti-RMP antibody

• Reactivity: Human
• Specificity: RMP antibody detects endogenous levels of total RMP protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 475

• Applicable Applications for anti-RMP antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human RMP.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using RMP antibody.Western blot analysis of extracts from NIH/3T3 cells, using RMP antibody.)

References

Van Leuven F., Genomics 54:511-520(1998). Ota T., Nat. Genet. 36:40-45(2004). Grimwood J., Nature 428:529-535(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 358001077
• NCBI GeneID: 8725
• NCBI Accession #: NP_001239570.1
• NCBI GenBank Nucleotide #: NM_001252641.1
• UniProt Accession #: O94763; Q8TC23; Q9UNU3; A8K805; H7BY42
• Molecular Weight: 53,447 Da
• NCBI Official Full Name: unconventional prefoldin RPB5 interactor 1 isoform c
• NCBI Official Synonym Full Names: URI1, prefoldin like chaperone
• NCBI Official Symbol: URI1
• NCBI Official Synonym Symbols: RMP; URI; NNX3; C19orf2; PPP1R19
• NCBI Protein Information: unconventional prefoldin RPB5 interactor 1
• UniProt Protein Name: Unconventional prefoldin RPB5 interactor 1
• Protein Family: RNA polymerase II subunit 5-mediating protein
• UniProt Gene Name: URI1
• UniProt Synonym Gene Names: C19orf2; NNX3; PPP1R19; RMP; URI; RPB5-mediating protein

NCBI Description

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

Uniprot Description

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.