anti-Human GluR6 Antibody | anti-GluR6 antibody

GluR6 Antibody

Cat. Num. AAA855801

• Gene Names: GRM6; mGlu6; CSNB1B; GPRC1F; MGLUR6
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GluR6; GluR6 Antibody; EAA4; GLR6; MGC74427; bA487F5.1 (glutamate receptor; ionotropic; kainate 2); excitatory amino acid receptor 4; glutamate receptor 6 isoform 1 precursor; glutamate receptor 6 isoform 2 precursor; anti-GluR6 antibody

• Reactivity: Human
• Specificity: GluR6 antibody detects endogenous levels of total GluR6 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 877

• Applicable Applications for anti-GluR6 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 500~1:1000; IHC: 1:50~1:100; ELISA: 1:5000
• Immunogen: The antiserum was produced against synthesized peptide derived from human GluR6.
• Preparation and Storage: Store at-20 degree C for 1 year

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR6 antibody.)

Western Blot (WB)

(Western blot analysis of extracts from mouse brain, using GluR6 antibody.)

References

Inga Everts, J. Neurosci., Feb 1999; 19: 916. Gregory D. Salinas, J. Biol. Chem., Dec 2006; 281: 40164-40173. Sheng Yan, J. Neurosci., Jan 2004; 24: 679. Xiao-Mei Liu, J. Biol. Chem., Jun 2006; 281: 17432-17445.

NCBI and Uniprot Product Information

• NCBI GI #: 110611176
• NCBI GeneID: 2916
• NCBI Accession #: NP_000834.2
• NCBI GenBank Nucleotide #: NM_000843.3
• UniProt Accession #: O15303
• Molecular Weight: 95,468 Da
• NCBI Official Full Name: metabotropic glutamate receptor 6
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 6
• NCBI Official Symbol: GRM6
• NCBI Official Synonym Symbols: mGlu6; CSNB1B; GPRC1F; MGLUR6
• NCBI Protein Information: metabotropic glutamate receptor 6
• UniProt Protein Name: Metabotropic glutamate receptor 6
• UniProt Gene Name: GRM6
• UniProt Synonym Gene Names: GPRC1F; MGLUR6; mGluR6

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Uniprot Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (). Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.