anti-Human FOXL2 Antibody | anti-FOXL2 antibody

FOXL2 (Phospho-Ser263) Antibody

Cat. Num. AAA859289

• Gene Names: FOXL2; BPES; PFRK; POF3; BPES1; PINTO
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
• Synonyms: FOXL2; FOXL2 (Phospho-Ser263) Antibody; BPES; BPES1; PFRK; PINTO; POF3; blepharophimosis; epicanthus inversus; and ptosis 1; forkhead box protein L2; anti-FOXL2 antibody

• Reactivity: Human
• Specificity: FOXL2 (Phospho-Ser263) antibody detects endogenous levels of FOXL2 only when phosphorylated at serine 263.
• Purity/Purification: Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 376

• Applicable Applications for anti-FOXL2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human FOXL2 around the phosphorylation site of serine 263 (V-Q-SP-M-A).
• All Sites: Human: Ser263
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from K562 cells, treated with Na3VO4 (0.3nM, 40mins), using FOXL2 (Phospho-Ser263) antibody.)

Product Categories/Family for anti-FOXL2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Crisponi L., Nat. Genet. 27:159-166(2001). Xu Y.; Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 12751477
• NCBI GeneID: 668
• NCBI Accession #: NP_075555.1
• NCBI GenBank Nucleotide #: NM_023067.3
• UniProt Accession #: P58012; Q4ZGJ3
• Molecular Weight: 38,772 Da
• NCBI Official Full Name: forkhead box protein L2
• NCBI Official Synonym Full Names: forkhead box L2
• NCBI Official Symbol: FOXL2
• NCBI Official Synonym Symbols: BPES; PFRK; POF3; BPES1; PINTO
• NCBI Protein Information: forkhead box protein L2
• UniProt Protein Name: Forkhead box protein L2
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXL2

NCBI Description

This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]

Uniprot Description

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (). Is a regulator of CYP19 expression (). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.