anti-Human COX11 Antibody | anti-COX11 antibody

COX11 Antibody

Cat. Num. AAA853007

• Gene Names: COX11; COX11P
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: COX11; COX11 Antibody; COX11P; cytochrome c oxidase assembly protein COX11; mitochondrial; anti-COX11 antibody

• Reactivity: Human
• Specificity: COX11 antibody detects endogenous levels of total COX11 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 276

• Applicable Applications for anti-COX11 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000; ELISA: 1:1000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human COX11.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from RAW264.7 cells, using COX11 antibody.)

Product Categories/Family for anti-COX11 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Petruzzella V., Genomics 54:494-504(1998). The MGC Project Team, Genome Res. 14:2121-2127(2004). Guo D., Mol. Pain 1:15-15(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 4758034
• NCBI GeneID: 1353
• NCBI Accession #: NP_004366.1
• NCBI GenBank Nucleotide #: NM_004375.4
• UniProt Accession #: Q9Y6N1; Q6FHB7; Q9BRX0; Q9UME8; D3DTY5; I3L220
• Molecular Weight: 26,133 Da
• NCBI Official Full Name: cytochrome c oxidase assembly protein COX11, mitochondrial isoform 1
• NCBI Official Synonym Full Names: COX11, cytochrome c oxidase copper chaperone
• NCBI Official Symbol: COX11
• NCBI Official Synonym Symbols: COX11P
• NCBI Protein Information: cytochrome c oxidase assembly protein COX11, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase assembly protein COX11, mitochondrial
• Protein Family: Cytochrome c oxidase assembly protein
• UniProt Gene Name: COX11

NCBI Description

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

Uniprot Description

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.