anti-Human CERKL Antibody | anti-CERKL antibody

CERKL Antibody

Cat. Num. AAA852070

• Gene Names: CERKL; RP26
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CERKL; CERKL Antibody; Ceramide kinase-like protein; anti-CERKL antibody

• Reactivity: Human
• Specificity: CERKL antibody detects endogenous levels of total CERKL protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 558

• Applicable Applications for anti-CERKL antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CERKL.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from A549 cells, using CERKL antibody.)

Product Categories/Family for anti-CERKL antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Tuson M., Am. J. Hum. Genet. 74:128-138(2004). Bornancin F., Biochim. Biophys. Acta 1687:31-43(2005). Ota T., Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 71896723
• NCBI GeneID: 375298
• NCBI Accession #: NP_001025482.1
• NCBI GenBank Nucleotide #: NM_001030311.2
• UniProt Accession #: Q49MI3; Q49MH9; Q49MI0; Q49MI1; Q49MI2; Q5DVJ2; Q5DVJ4; Q5DVJ5; Q6UZF6; Q6ZP59; B2RPL2; B4DEY1
• Molecular Weight: 57,632 Da
• NCBI Official Full Name: ceramide kinase-like protein isoform 2
• NCBI Official Synonym Full Names: ceramide kinase like
• NCBI Official Symbol: CERKL
• NCBI Official Synonym Symbols: RP26
• NCBI Protein Information: ceramide kinase-like protein
• UniProt Protein Name: Ceramide kinase-like protein
• Protein Family: Ceramide kinase-like protein
• UniProt Gene Name: CERKL

NCBI Description

This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]

Uniprot Description

Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.