anti-Human ATXN2 Antibody | anti-ATXN2 antibody

ATXN2 Antibody

Cat. Num. AAA8514527

• Gene Names: ATXN2; ATX2; SCA2; TNRC13
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: ATXN2; ATXN2 Antibody; ATX2; SCA2; Spinocerebellar ataxia type 2 protein; anti-ATXN2 antibody

• Reactivity: Human
• Specificity: ATXN2 Antibody detects endogenous levels of total ATXN2
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 1006

• Applicable Applications for anti-ATXN2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthesized peptide
• Preparation and Storage: Store at-20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HepG2 cells, Jurkat cells and 293 cells, using ATXN2 antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 858437832
• NCBI GeneID: 6311
• NCBI Accession #: NP_001297052.1
• NCBI GenBank Nucleotide #: NM_001310123.1
• UniProt Accession #: Q99700; Q24JQ7; Q6ZQZ7; Q99493; A6NLD4
• Molecular Weight: 140 KD
• NCBI Official Full Name: ataxin-2 isoform 3
• NCBI Official Synonym Full Names: ataxin 2
• NCBI Official Symbol: ATXN2
• NCBI Official Synonym Symbols: ATX2; SCA2; TNRC13
• NCBI Protein Information: ataxin-2
• UniProt Protein Name: Ataxin-2
• Protein Family: Ataxin
• UniProt Gene Name: ATXN2
• UniProt Synonym Gene Names: ATX2; SCA2; TNRC13

NCBI Description

This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Uniprot Description

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.