Human Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1) Antibody Pair Kit | NOD1 antibody pair kit

Human Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1) Antibody Pair Kit (with Standard)

Cat. Num. AAA2104160

• Gene Names: NOD1; CARD4; NLRC1; CLR7.1
• Reactivity: Human
• Applications: ELISA, ELISA
• Synonyms: Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1); Human Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1) Antibody Pair Kit (with Standard); CARD4; CLR7.1; NLRC1; Caspase Recruitment Domain Family; Member 4; Nucleotide-Binding Oligomerization Domain; Leucine Rich Repeat And CARD Domain Containing 1; NOD1 antibody pair kit

• Reactivity: Human

• Applicable Applications for NOD1 antibody pair kit: ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
• Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids
• Detection Range: 31.2-2000ng/mL
• Standard: Recombinant NOD1 (Lyophilized, 1 vial-10ug)
• Capture Antibody: Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
• Detection Antibody: Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
• Producte Usage: Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
• Antibody Support Pack: Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Product Categories/Family for NOD1 antibody pair kit

Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 5174617
• NCBI GeneID: 10392
• NCBI Accession #: NP_006083.1
• NCBI GenBank Nucleotide #: NM_006092.3
• UniProt Accession #: Q9Y239; Q549U4; Q8IWF5; B4DTU3
• Molecular Weight: 27,949 Da
• NCBI Official Full Name: nucleotide-binding oligomerization domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: nucleotide binding oligomerization domain containing 1
• NCBI Official Symbol: NOD1
• NCBI Official Synonym Symbols: CARD4; NLRC1; CLR7.1
• NCBI Protein Information: nucleotide-binding oligomerization domain-containing protein 1
• UniProt Protein Name: Nucleotide-binding oligomerization domain-containing protein 1
• Protein Family: Nucleotide-binding oligomerization domain-containing protein
• UniProt Gene Name: NOD1
• UniProt Synonym Gene Names: CARD4

NCBI Description

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

Uniprot Description

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.