TNF Receptor Type II Active Protein | TNF active protein
TNF Receptor Type II protein
Applications
User optimized
Purity
> 97% pure
Synonyms
TNF Receptor Type II; TNF Receptor Type II protein; CD120b protein; Soluble Tumor Necrosis Factor type II protein; p75 protein; TNFR75 protein; TNFRSF1B protein; p80 protein; TNF Receptor II protein; TNFR80 protein; TNF Receptor 2 protein; TNF active protein
Host
Human
Purity/Purification
> 97% pure
Form/Format
Lyophilized from 10mM tris, pH 8.0 with 50mM NaCl. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers.
Sequence
Region of TNF Receptor Type II protein corresponding to amino acids MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP.
Applicable Applications for TNF active protein
User optimized
Protein Type
Recombinant
Biological Significance
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-alpha but manifests a lower affinity to TNF-beta. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-alpha induced activities by acting as a decoy receptor.
Bioactivity
Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in Mouse L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha, is 0.125 ug/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for TNF active protein
Purified recombinant Human TNF Receptor Type II protein
Product Categories/Family for TNF active protein
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Product Notes
The TNF (Catalog #AAA537549) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TNF Receptor Type II can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the TNF for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of TNF Receptor Type II protein correspond ing to amino acids MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP. It is sometimes possible for the material contained within the vial of "TNF Receptor Type II, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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