MIS RII, Fc Chimera Active Protein
MIS RII, Fc Chimera, Recombinant, Human (Mullerian Inhibiting Substance Type II Teceptor, AMHRII, anti-Mullerian Hormone Type II Receptor)
Reactivity
Human
Applications
ELISA
Purity
Highly Purified90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin 1EU per 1ug of protein (LAL method).
Synonyms
MIS RII; Fc Chimera; Recombinant; Human (Mullerian Inhibiting Substance Type II Teceptor; AMHRII; anti-Mullerian Hormone Type II Receptor); Fc Chimera active protein
Reactivity
Human
Purity/Purification
Highly Purified
90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin 1EU per 1ug of protein (LAL method).
90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin 1EU per 1ug of protein (LAL method).
Form/Format
Supplied as a lyophilized powder in PBS. Reconstitute with sterile PBS to 0.1mg/ml.
Applicable Applications for MIS RII, Fc Chimera active protein
ELISA (EL/EIA)
Application Notes
Suitable for use in ELISA.
Activity
Measured by its ability to bind rhMIS in a functional ELISA.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C or lower. Powder is stable for 12 months at -20 degree C or lower. Reconstituted product under sterile conditions is stable for 1 month at 4 degree C or for 3 months at -20 degree C or lower.
Related Product Information for MIS RII, Fc Chimera active protein
Human MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is an 82kD serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-Beta superfamily (1). The MIS RII precursor is 573 amino acids (aa) in length, with a 17 aa signal sequence, a 127 aa extracellular region that also contains two potential N-linked glycosylation sites, a 26 aa transmembrane region, and a 403 aa cytoplasmic region that contains the serine/threonine kinase domain (1). Human MIS RII shares 82%, 78%, and 77% aa sequence identity with rabbit, mouse, and rat MIS RII, respectively. It is expressed in the mesenchyme surrounding the fetal Mullerian duct, in fetal and postnatal granulosa cells, and in Sertoli cells (1-6). MIS RII is a receptor for Mullerian inhibitor substance (MIS), also known as anti-Mullerian hormone (AMH), which is responsible for regression of the Mullerian duct, the anlagen of the uterus, Fallopian tubes, and upper vagina in male fetuses (1-6). Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), an extremely rare form of pseudohermaphroditism (5, 6)
Product Categories/Family for MIS RII, Fc Chimera active protein
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Product Notes
The MIS RII, Fc Chimera (Catalog #AAA636937) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The MIS RII, Fc Chimera, Recombinant, Human (Mullerian Inhibiting Substance Type II Teceptor, AMHRII, anti-Mullerian Hormone Type II Receptor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MIS RII, Fc Chimera can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Researchers should empirically determine the suitability of the MIS RII, Fc Chimera for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MIS RII, Fc Chimera, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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