MIP1 beta active protein
MIP1 beta protein
Gene Names
Ccl4; Scya4; Mip1-b
Applications
User optimized
Purity
> 98% pure
Synonyms
MIP1 beta; MIP1 beta protein; Macrophage Inflammatory Protein-1beta protein; CCL4 protein; MIP beta 1 protein; MIP-1 beta protein; ACT-2 protein; MIP beta-1; MIP beta 1; MIP beta-1 protein; MIP1 beta active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Sequence
Region of MIP1 beta protein corresponding to amino acids APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN.
Sequence Length
92
Applicable Applications for MIP1 beta active protein
User optimized
Protein Type
Recombinant
Biological Significance
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 ug/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for MIP1 beta active protein
Purified recombinant Human MIP1 beta protein
Product Categories/Family for MIP1 beta active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
7.8 kDa
NCBI Official Full Name
macrophage inflammatory protein-1 beta
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 4
NCBI Official Symbol
Ccl4
NCBI Official Synonym Symbols
Scya4; Mip1-b
NCBI Protein Information
C-C motif chemokine 4
UniProt Protein Name
C-C motif chemokine 4
UniProt Gene Name
Ccl4
UniProt Synonym Gene Names
Mip1b; Scya4; MIP-1-beta
UniProt Entry Name
CCL4_RAT
NCBI Description
a cytokine that is up-regulated during the inflammatory response; may be involved in intrapulmonary recruitment of neutrophils [RGD, Feb 2006]
Uniprot Description
Monokine with inflammatory and chemokinetic properties.
Research Articles on MIP1 beta
Similar Products
Product Notes
The MIP1 beta ccl4 (Catalog #AAA539610) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MIP1 beta can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the MIP1 beta ccl4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of MIP1 beta protein correspond ing to amino acids APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN. It is sometimes possible for the material contained within the vial of "MIP1 beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
