IL7 active protein

IL7 protein

Cat. Num. AAA538088

• Gene Names: IL7; IL-7
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL7; IL7 protein; Interleukin 7 protein; IL-7 protein; LP-1 protein; IL 7 protein; pre-B cell factor protein; IL 7; Lymphopoietin 1protein; IL-7; IL7 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Lyophilized from 10 mM CH3COOH. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.
• Sequence: Region of IL7 protein corresponding to amino acids MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH.
• Sequence Length: 177

• Applicable Applications for IL7 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL2. Human and Mouse IL7 is cross-species reactive.
• Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse 2E8 cells is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL7 active protein

Purified recombinant Human IL7 protein

Product Categories/Family for IL7 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4504677
• NCBI GeneID: 3574
• NCBI Accession #: NP_000871.1
• NCBI GenBank Nucleotide #: NM_000880.3
• UniProt Accession #: P13232; Q5FBY5; Q5FBY9; A0N0L3
• Molecular Weight: 17.4 kDa
• NCBI Official Full Name: interleukin-7 isoform 1
• NCBI Official Synonym Full Names: interleukin 7
• NCBI Official Symbol: IL7
• NCBI Official Synonym Symbols: IL-7
• NCBI Protein Information: interleukin-7
• UniProt Protein Name: Interleukin-7
• Protein Family: Interleukin
• UniProt Gene Name: IL7
• UniProt Synonym Gene Names: IL-7
• UniProt Entry Name: IL7_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Uniprot Description

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Cell cycle regulation; Apoptosis; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; organ morphogenesis; T cell lineage commitment; cell-cell signaling; positive regulation of T cell differentiation; homeostasis of number of cells within a tissue; regulation of gene expression; positive regulation of cell proliferation; negative regulation of catalytic activity; positive regulation of B cell proliferation; bone resorption; negative regulation of apoptosis