IL20 active protein

IL20 protein

Cat. Num. AAA539519

• Gene Names: IL20; IL-20; IL10D; ZCYTO10
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL20; IL20 protein; Interleukin 20 protein; IL-20 protein; IL-20; IL 20 protein; IL 20; IL20 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Supplied as lyophilized powder.
• Sequence: Region of IL20 protein corresponding to amino acids MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE.
• Sequence Length: 176

• Applicable Applications for IL20 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL20 is a member of the IL10 family of regulatory cytokines which includes IL10, IL19, IL20, IL22, IL24 and IL26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL20 signals through a receptor system composed of type I IL20R-a and type II IL20R-beta. Over-expression of IL20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease.
• Bioactivity: Determined by its ability to activate STAT following receptor ligand interaction.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL20 active protein

Purified recombinant Human IL20 protein

Product Categories/Family for IL20 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 31083166
• NCBI GeneID: 50604
• NCBI Accession #: NP_061194.2
• NCBI GenBank Nucleotide #: NM_018724.3
• UniProt Accession #: Q9NYY1; Q17RB3; Q2THG6; Q96QZ6
• Molecular Weight: 35.2 kDa
• NCBI Official Full Name: interleukin-20
• NCBI Official Synonym Full Names: interleukin 20
• NCBI Official Symbol: IL20
• NCBI Official Synonym Symbols: IL-20; IL10D; ZCYTO10
• NCBI Protein Information: interleukin-20
• UniProt Protein Name: Interleukin-20
• Protein Family: Interleukin
• UniProt Gene Name: IL20
• UniProt Synonym Gene Names: ZCYTO10; IL-20
• UniProt Entry Name: IL20_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Uniprot Description

IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-20 receptor binding; interleukin-22 receptor binding; cytokine activity

Biological Process: positive regulation of osteoclast differentiation; positive regulation of epidermal cell differentiation; regulation of inflammatory response; positive regulation of JAK-STAT cascade; immune response; inflammatory response; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of keratinocyte differentiation