IL18 active protein

Purified recombinant Human IL18 protein

Cat. Num. AAA5308747

• Gene Names: IL18; IGIF; IL-18; IL-1g; IL1F4
• Purity: > 98% pure; Purified using a proprietary chromatographic technique.
• Synonyms: IL18; Purified recombinant Human IL18 protein; IL18 protein; IL18 active protein

• Host: Human
• Purity/Purification: > 98% pure; Purified using a proprietary chromatographic technique.
• Form/Format: Sterile filtered and lyophilized from PBS
• Sequence Length: 189

• Expression: E Coli
• Bioactivity: The ED50 as determined by dose-dependent stimulation of the IFNg by human PBMC co-stimulated with rh-IL-12 was found to be 5 ng/ml
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Product Categories/Family for IL18 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 342349321
• NCBI GeneID: 3606
• NCBI Accession #: NP_001230140.1
• NCBI GenBank Nucleotide #: NM_001243211.1
• UniProt Accession #: Q14116; O75599; Q6FGY3; Q6WWJ7
• Molecular Weight: 21,896 Da
• NCBI Official Full Name: interleukin-18 isoform 2
• NCBI Official Synonym Full Names: interleukin 18
• NCBI Official Symbol: IL18
• NCBI Official Synonym Symbols: IGIF; IL-18; IL-1g; IL1F4
• NCBI Protein Information: interleukin-18
• UniProt Protein Name: Interleukin-18
• Protein Family: Interleukin
• UniProt Gene Name: IL18
• UniProt Synonym Gene Names: IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma

NCBI Description

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Uniprot Description

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cytosol; extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding

Biological Process: activation of protein kinase B; angiogenesis; cell-cell signaling; chemokine biosynthetic process; cholesterol homeostasis; granulocyte macrophage colony-stimulating factor biosynthetic process; immune response; inflammatory response; interferon-gamma biosynthetic process; interleukin-13 biosynthetic process; interleukin-2 biosynthetic process; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; positive regulation of activated T cell proliferation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell proliferation; positive regulation of NK T cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of tissue remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell adhesion; sleep; T-helper 1 type immune response; T-helper 2 type immune response