Fibrinogen Active Protein | TNXB active protein

Fibrinogen protein

Cat. Num. AAA537230

• Gene Names: TNXB; XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: Fibrinogen; Fibrinogen protein; Fg protein; TNXB active protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: 20mM Sodium Citrate-HCl buffer, pH 7.4. This is von Willebrand Factor and Fibronectin Depleted.
• Sequence Length: 211

• Applicable Applications for TNXB active protein: User optimized
• Source Note: Human plasma
• Protein Type: Native
• Biological Significance: Fibrinogen (factor I) is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for converting fibrinogen into fibrin.
• Bioactivity: 100% Clottable
• Biohazard Information: Raw materials tested negative against HIV1/2, HCV and HbsAg. Donors are screened for CJD.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles

Related Product Information for TNXB active protein

Highly purified native Fibrinogen protein

Product Categories/Family for TNXB active protein

Immunology; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 394794
• NCBI GeneID: 7148
• UniProt Accession #: Q9UE34; P22105
• Molecular Weight: 23,916 Da
• NCBI Official Full Name: fibrinogen
• NCBI Official Synonym Full Names: tenascin XB
• NCBI Official Symbol: TNXB
• NCBI Official Synonym Symbols: XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS
• NCBI Protein Information: tenascin-X
• UniProt Protein Name: Fibrinogen
• Protein Family: Fibrinogen
• UniProt Entry Name: Q9UE34_HUMAN

NCBI Description

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TNXB: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. Defects in TNXB are the cause of tenascin-X deficiency (TNXD). TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers- Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Belongs to the tenascin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; fibrillar collagen; intracellular

Molecular Function: integrin binding; heparin binding; collagen binding

Biological Process: elastic fiber assembly; cell-cell adhesion; triacylglycerol metabolic process; collagen fibril organization; collagen metabolic process; cell-matrix adhesion; regulation of JNK activity; fibril organization and biogenesis; cell adhesion; actin cytoskeleton organization and biogenesis; fatty acid metabolic process

Disease: Ehlers-danlos-like Syndrome Due To Tenascin-x Deficiency; Vesicoureteral Reflux 8