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FGF6 active protein

FGF6 protein

Gene Names
FGF6; HST2; HBGF-6
Applications
User optimized
Purity
> 95% pure
Synonyms
FGF6; FGF6 protein; Fibroblast Growth Factor-6 protein; FGF 6; FGF 6 protein; FGF-6; HST-2 protein; HBGF-6 protein; FGF-6 protein; FGF6 active protein
Ordering
For Research Use Only!
Host
Human
Purity/Purification
> 95% pure
Form/Format
Supplied as a lyophilized powder.
Sequence
Region of FGF6 protein corresponding to amino acids MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI.
Sequence Length
208
Applicable Applications for FGF6 active protein
User optimized
Protein Type
Recombinant
Biological Significance
FGF6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4.
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for FGF6 active protein
Purified recombinant Human FGF6 protein
Product Categories/Family for FGF6 active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
18.7 kDa
NCBI Official Full Name
fibroblast growth factor 6
NCBI Official Synonym Full Names
fibroblast growth factor 6
NCBI Official Symbol
FGF6
NCBI Official Synonym Symbols
HST2; HBGF-6
NCBI Protein Information
fibroblast growth factor 6
UniProt Protein Name
Fibroblast growth factor 6
Protein Family
UniProt Gene Name
FGF6
UniProt Synonym Gene Names
HST2; HSTF2; FGF-6; HST-2; HSTF-2; HBGF-6
UniProt Entry Name
FGF6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF6: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Belongs to the heparin-binding growth factors family.

Protein type: Oncoprotein; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular space; extracellular region; sarcolemma

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; signal transduction; myoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; cartilage condensation

Research Articles on FGF6

Similar Products

Product Notes

The FGF6 fgf6 (Catalog #AAA539444) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's FGF6 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the FGF6 fgf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of FGF6 protein correspond ing to amino acids MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI. It is sometimes possible for the material contained within the vial of "FGF6, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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