FGF10 active protein

Purified recombinant Human FGF10 protein

Cat. Num. AAA5308650

• Purity: Purified using a proprietary chromatographic technique.
• Synonyms: FGF10; Purified recombinant Human FGF10 protein; FGF10 protein; FGF10 active protein

• Host: Human
• Purity/Purification: Purified using a proprietary chromatographic technique.
• Form/Format: Supplied sterile filtered and lyophilized with no additives. This protein may appear as a haze or film, which you may not see at the bottom of the vial
• Sequence Length: 208

• Expression: E Coli
• Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is < 1 ng/ml, corresponding to a specific activity of > 1 x 10^6 units/mg
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Product Categories/Family for FGF10 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4758360
• NCBI GeneID: 2255
• NCBI Accession #: NP_004456.1
• NCBI GenBank Nucleotide #: NM_004465.1
• UniProt Accession #: O15520; Q6FHR3; Q6FHT6; Q96P59; C7FDY0
• Molecular Weight: 23,436 Da
• NCBI Official Full Name: fibroblast growth factor 10
• NCBI Official Synonym Full Names: fibroblast growth factor 10
• NCBI Official Symbol: FGF10
• NCBI Protein Information: fibroblast growth factor 10
• UniProt Protein Name: Fibroblast growth factor 10
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF10
• UniProt Synonym Gene Names: FGF-10

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p12

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 2 fibroblast growth factor receptor binding

Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; branching morphogenesis of a tube; epithelial cell proliferation; fibroblast growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; lacrimal gland development; MAPKKK cascade; mesonephros development; metanephros development; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of ATPase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte migration; positive regulation of lymphocyte proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of urothelial cell proliferation; radial glial cell differentiation; regulation of phosphoinositide 3-kinase cascade; regulation of saliva secretion; salivary gland development; thymus development; urothelial cell proliferation; wound healing

Disease: Aplasia Of Lacrimal And Salivary Glands; Lacrimoauriculodentodigital Syndrome