Mouse HtrA serine peptidase 2 ELISA Kit | HTRA2 elisa kit
Mouse Serine protease HTRA2, mitochondrial, HTRA2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HTRA2: a serine proteinase that normally resides in mitochondrial membranes. It exists in two populations in mitochondria: as an unprocessed form probably attached to the inner mitochondrial membrane through a N-terminal transmembrane domain, and as a processed form containing a reaper motif at its N-terminus. Following apoptotic stimuli it is autoproteolytically activated and released into the cytosol, where it promotes programmed cell death in caspase-dependent and -independent manners. The amino-terminal reaper motif binds to the IAP (inhibitor of apoptosis) proteins cIAP1, cIAP2, and and XIAP, disrupting IAP-caspase complexes in a manner similar to Smac/DIABLO. Phosphorylation by the protein kinase Akt attenuates its serine protease and pro-apoptotic activities. The PDZ domain mediates interaction with Mxi2, an alternatively spliced form of the p38 stress-activated kinase. In contrast to its pro-apoptotic effects, targeted deletion in mice indicates that it is involved in protection against cell stress in striatial neurons. Defects in HTRA2 are the cause of Parkinson disease 13 (PARK13). Four alternatively spliced human isoforms have been described.
Protein type: Membrane protein, integral; Protease; EC 3.4.21.108; Mitochondrial
Cellular Component: internal side of plasma membrane; cytoskeleton; membrane; mitochondrion; integral to membrane; mitochondrial intermembrane space; intracellular; cytosol; chromatin; nucleus
Molecular Function: peptidase activity; protein binding; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity
Biological Process: mitochondrion organization and biogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; cellular protein catabolic process; apoptosis; adult locomotory behavior; forebrain development; regulation of multicellular organism growth; positive regulation of caspase activity; neuron development; proteolysis; adult walking behavior
Research Articles on HTRA2
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Product Notes
The Mouse HTRA2 htra2 (Catalog #AAA9338484) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338484 ELISA Kit recognizes Mouse HTRA2. It is sometimes possible for the material contained within the vial of "HtrA serine peptidase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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