5-hydroxytryptamine receptor 3A (Htr3a) Recombinant Protein | Htr3a recombinant protein

Recombinant Rat 5-hydroxytryptamine receptor 3A (Htr3a)

• Gene Names: Htr3a; 5HT3; Htr3; 5-HT3; 5-HT3A
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 5-hydroxytryptamine receptor 3A (Htr3a); Recombinant Rat 5-hydroxytryptamine receptor 3A (Htr3a); Recombinant 5-hydroxytryptamine receptor 3A (Htr3a); 5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R Serotonin receptor 3A Serotonin-gated ion channel receptor; Htr3a recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 24-483
• Sequence: SRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
• Sequence Length: 483

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 139947611
• NCBI GeneID: 79246
• NCBI Accession #: NP_077370.2
• NCBI GenBank Nucleotide #: NM_024394.2
• UniProt Accession #: P35563
• Molecular Weight: 55,428 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 3A
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
• NCBI Official Symbol: Htr3a
• NCBI Official Synonym Symbols: 5HT3; Htr3; 5-HT3; 5-HT3A
• NCBI Protein Information: 5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3R; 5-HT3-A; 5-HT3 receptor; serotonin receptor 3A; serotonin-gated ion channel receptor
• UniProt Protein Name: 5-hydroxytryptamine receptor 3A
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: Htr3a
• UniProt Synonym Gene Names: 5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R
• UniProt Entry Name: 5HT3A_RAT

NCBI Description

receptor for 5-hydroxytryptamine (serotonin); functions as a ligand-gated ion channel [RGD, Feb 2006]

Uniprot Description

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, cation

Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction

Molecular Function: serotonin-activated cation-selective channel activity; serotonin binding; voltage-gated potassium channel activity; serotonin receptor activity

Biological Process: synaptic transmission; response to ethanol; response to cocaine; cation transport; serotonin receptor signaling pathway