SDS-Page
HTATIP2 recombinant protein
HTATIP2, 1-242aa, Human, His tag, E Coli
Gene Names
HTATIP2; CC3; TIP30; SDR44U1
Applications
SDS-Page
Purity
> 95% by SDS- PAGE
Synonyms
HTATIP2; 1-242aa; Human; His tag; E Coli; Oxidoreductase HTATP2; CC3; TIP30; SDR44u1; HTATIP 2; HTATIP-2; CC-3; TIP 30; TIP-30; HTATIP2 recombinant protein
Host
E Coli
Purity/Purification
> 95% by SDS- PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Concentration
1 mg/ml (determined by Bradford assay) (varies by lot)
Sequence
MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
Sequence Length
242
Applicable Applications for HTATIP2 recombinant protein
SDS-PAGE
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
SDS-Page
Related Product Information for HTATIP2 recombinant protein
HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy. Recombinant human HTATIP2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques
Product Categories/Family for HTATIP2 recombinant protein
References
Shtivelman E., et al. (1997) Oncogene. 14 (18):2167-73. ; Xiao H., et al. (1998) Proc Natl Acad Sci u S A. 95 (5):2146-2151.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
29.3 kDa (262aa), confirmed by MALDI-TOF
NCBI Official Full Name
HTATIP2 protein
NCBI Official Synonym Full Names
HIV-1 Tat interactive protein 2
NCBI Official Symbol
HTATIP2
NCBI Official Synonym Symbols
CC3; TIP30; SDR44U1
NCBI Protein Information
oxidoreductase HTATIP2
UniProt Protein Name
Oxidoreductase HTATIP2
Protein Family
UniProt Gene Name
HTATIP2
Uniprot Description
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Research Articles on HTATIP2
Similar Products
Product Notes
The HTATIP2 htatip2 (Catalog #AAA203512) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His-tag. AAA Biotech's HTATIP2 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the HTATIP2 htatip2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP. It is sometimes possible for the material contained within the vial of "HTATIP2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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