HSPBP1 recombinant protein

HSPBP1, 1-362aa, Human, His tag, E Coli

Cat. Num. AAA203420

• Gene Names: HSPBP1; FES1
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: HSPBP1; 1-362aa; Human; His tag; E Coli; Hsp70-binding protein 1; HSPBP; FES; Hsp70-binding protein 1 500019G21Rik; FES1; Heat shock protein 70 binding protein; Heat shock protein 70 interacting protein; Heat shock protein binding protein 1; Heat-shock 70-KD protein-binding protein 1; Hsp 70 binding protein; Hsp 70 interacting protein; Hsp70 binding protein 1; Hsp70 binding protein 2; Hsp70 interacting protein 1; Hsp70 interacting protein 2; HSPA (heat shock 70kDa) binding protein; cytoplasmic cochaperone 1; HSPA-binding protein 1; HspBP1; HspBP2; ; HSPBP1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2mM DTT, 30% glycerol, 2mM EDTA, 0.1M NaCl
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MSDEGSRGSR LPLALPPASQ GCSSGGGGGG GGGSSAGGSG NSRPPRNLQG LLQMAITAGS EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG AAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKLLRLLD RDACDTVRVK ALFAISCLVR EQEAGLLQFL RLDGFSVLMR AMQQQVQKLK VKSAFLLQNL LVGHPEHKGT LCSMGMVQQL VALVRTEHSP FHEHVLGALC SLVTDFPQGV RECREPELGL EELLRHRCQL LQQHEEYQEE LEFCEKLLQT CFSSPADDSM DR
• Sequence Length: 362

• Applicable Applications for HSPBP1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for HSPBP1 recombinant protein

Hsp70-binding protein 1, also known as HSPBP1, belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for HSP 70, which exhibit varying degrees of compartment and species specificity. It is localized primarily in cytoplasm and nucleus but is also found extracellularly. HspBP1 binds to HSP 70, inhibits its activity and promotes dissociation of nucleotides from the HSP 70 ATPase domain. It is mainly expressed in heart and skeletal muscle. Recombinant human HSPBP1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for HSPBP1 recombinant protein

Heat Shock Proteins

References

Ewdonin A., et al. (2009) Biol Cell. 101 (6):351-60.; Souza AP., et al. (2009) Cell Stress Chaperones. 14 (3): 301-10.;

NCBI and Uniprot Product Information

• NCBI GI #: 12654787
• NCBI GeneID: 23640
• Molecular Weight: 41.6 kDa (382aa)
• NCBI Official Full Name: HSPBP1 protein
• NCBI Official Synonym Full Names: HSPA (Hsp70) binding protein 1
• NCBI Official Symbol: HSPBP1
• NCBI Official Synonym Symbols: FES1
• NCBI Protein Information: hsp70-binding protein 1
• UniProt Protein Name: Hsp70-binding protein 1
• Protein Family: Hsp70-binding protein
• UniProt Gene Name: HSPBP1
• UniProt Synonym Gene Names: HSPBP; HspBP1; HspBP2

Uniprot Description

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.