Heat Shock Protein 90kDa Beta 1 (HSP90b1) Recombinant Protein | HSP90b1 recombinant protein

Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1)

Cat. Num. AAA2097626

• Gene Names: Hsp90b1; TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
• Reactivity: Mouse
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Heat Shock Protein 90kDa Beta 1 (HSP90b1); Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1); HSP90-B1; ECGP; GP96; GRP94; TRA1; Glycoprotein 96; Tumor Rejection Antigen(gp96)1;94 kDa glucose-regulated protein; Endoplasmin; HSP90b1 recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 802

• Applicable Applications for HSP90b1 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Ala234~Lys474

SDS-Page

Product Categories/Family for HSP90b1 recombinant protein

Signal transduction; Immune molecule; Developmental science

NCBI and Uniprot Product Information

• NCBI GI #: 6755863
• NCBI GeneID: 22027
• NCBI Accession #: NP_035761.1
• NCBI GenBank Nucleotide #: NM_011631.1
• UniProt Accession #: P08113; P11427
• Molecular Weight: Predicted Molecular Weight: 32.1kDa
• NCBI Official Full Name: endoplasmin
• NCBI Official Synonym Full Names: heat shock protein 90, beta (Grp94), member 1
• NCBI Official Symbol: Hsp90b1
• NCBI Official Synonym Symbols: TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
• NCBI Protein Information: endoplasmin
• UniProt Protein Name: Endoplasmin
• Protein Family: Endoplasmin
• UniProt Gene Name: Hsp90b1
• UniProt Synonym Gene Names: Grp94; Tra-1; Tra1; GRP-94; ERp99

Uniprot Description

GRP94: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP. Interacts with TLR4 and TLR9, but not with TLR3. Belongs to the heat shock protein 90 family.

Protein type: Apoptosis; Heat shock protein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10 C1|10 43.05 cM

Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; extracellular matrix; focal adhesion; membrane; midbody; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; smooth endoplasmic reticulum

Molecular Function: ATP binding; low-density lipoprotein receptor binding; nucleotide binding; protein binding; protein phosphatase binding; RNA binding; unfolded protein binding

Biological Process: actin rod assembly; cellular response to ATP; ER-associated protein catabolic process; negative regulation of apoptosis; protein folding; regulation of phosphoprotein phosphatase activity; response to hypoxia; response to stress; retrograde protein transport, ER to cytosol