HSP90 Blocking Peptide | HSP90AA1 blocking peptide

HSP90 Blocking Peptide (Center)

• Synonyms: HSP90; HSP90 Blocking Peptide (Center); Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; HSP90AA1; HSP90A; HSPC1; HSPCA; HSP90AA1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 299-311 of HUMAN HSP90AA1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 733

• Cellular Location: Cytoplasm. Melanosome. Cell membrane. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HSP90AA1 blocking peptide

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 122065208
• NCBI GeneID: 103692716
• UniProt Accession #: P07900; Q91XW0
• Molecular Weight: 84,815 Da
• NCBI Official Full Name: Heat shock protein HSP 90-alpha
• NCBI Official Synonym Full Names: heat shock protein HSP 90-alpha
• NCBI Official Symbol: LOC103692716
• NCBI Protein Information: heat shock protein HSP 90-alpha
• UniProt Protein Name: Heat shock protein HSP 90-alpha
• Protein Family: Heat shock protein
• UniProt Gene Name: Hsp90aa1
• UniProt Synonym Gene Names: Hsp86; Hspca; HSP 86; HSP86
• UniProt Entry Name: HS90A_RAT

Uniprot Description

HSP90A: a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau.

Protein type: Chaperone; Heat shock protein

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cell soma; cell surface; cytoplasm; cytosol; extracellular matrix; intracellular; membrane; myelin sheath; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: ATP binding; ATPase activity; dATP binding; glycoprotein binding; GTP binding; GTPase binding; histone deacetylase binding; identical protein binding; mRNA binding; nitric-oxide synthase regulator activity; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein-tyrosine kinase activity; Rho GDP-dissociation inhibitor binding; sulfonylurea receptor binding; tau protein binding; TPR domain binding; unfolded protein binding

Biological Process: chaperone-mediated protein complex assembly; neuron migration; positive regulation of cell size; positive regulation of nitric oxide biosynthetic process; positive regulation of protein import into nucleus, translocation; protein folding; protein import into mitochondrial outer membrane; regulation of protein ubiquitination; response to antibiotic; response to cocaine; response to cold; response to drug; response to estrogen stimulus; response to heat; response to salt stress; skeletal muscle contraction