Haptoglobin Related Protein (HPR) Recombinant Protein | HPR recombinant protein

Recombinant Haptoglobin Related Protein (HPR)

Cat. Num. AAA2010229

• Gene Names: HPR; HP; A-259H10.2
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Haptoglobin Related Protein (HPR); Recombinant Haptoglobin Related Protein (HPR); HPR recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGSEF-SDDRFPKPPE IANGYVEHLF RYQCKNYYRL RTEGDGVYTL NDKKQWINKA VGDKLP
• Sequence Length: 348

• Applicable Applications for HPR recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Ser30~Pro85 (Accession # P00739) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 45580723
• NCBI GeneID: 3250
• NCBI Accession #: NP_066275.3
• NCBI GenBank Nucleotide #: NM_020995.3
• UniProt Accession #: P00739; Q7LE20; Q92658; Q92659; Q9ULB0
• Molecular Weight: 8.2kDa
• NCBI Official Full Name: haptoglobin-related protein
• NCBI Official Synonym Full Names: haptoglobin-related protein
• NCBI Official Symbol: HPR
• NCBI Official Synonym Symbols: HP; A-259H10.2
• NCBI Protein Information: haptoglobin-related protein; Haptoglobin-related locus
• UniProt Protein Name: Haptoglobin-related protein
• Protein Family: Haptoglobin-related protein
• UniProt Gene Name: HPR
• UniProt Entry Name: HPTR_HUMAN

NCBI Description

This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

Uniprot Description

HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region

Molecular Function: hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; metabolic process