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Horse Serine/Threonine-Protein Kinase PINK1, Mitochondrial (PINK1) ELISA Kit | PINK1 elisa kit

Horse Serine/Threonine-Protein Kinase PINK1, Mitochondrial (PINK1) ELISA Kit

Reactivity
Horse
Synonyms
Serine/Threonine-Protein Kinase PINK1; Mitochondrial (PINK1); Horse Serine/Threonine-Protein Kinase PINK1; Mitochondrial (PINK1) ELISA Kit; PINK1 elisa kit
Ordering
 
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For Research Use Only!
Reactivity
Horse
Preparation and Storage
Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
Molecular Weight
30,104 Da
NCBI Official Full Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt Protein Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt Gene Name
PINK1
UniProt Entry Name
PINK1_HUMAN

Uniprot Description

PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Membrane protein, integral; Protein kinase, Other; EC 2.7.11.1; Mitochondrial; Other group; NKF2 family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: axon; chromatin; cytoplasm; cytoskeleton; cytosol; integral to mitochondrial outer membrane; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; nucleus; perinuclear region of cytoplasm; TORC2 complex; ubiquitin ligase complex

Molecular Function: ATP binding; kinase activity; magnesium ion binding; protease activator activity; protease binding; protein binding; protein kinase activity; protein kinase B binding; protein serine/threonine kinase activity; ubiquitin protein ligase binding

Biological Process: activation of protein kinase B; macroautophagy; macromitophagy; mitochondrion degradation; mitochondrion organization and biogenesis; negative regulation of JNK cascade; negative regulation of macroautophagy; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of dopamine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid dephosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of synaptic transmission, dopaminergic; positive regulation of transcription factor activity; positive regulation of translation; positive regulation of ubiquitin-protein ligase activity; protein amino acid phosphorylation; protein stabilization; protein ubiquitination; regulation of hydrogen peroxide metabolic process; regulation of mitochondrial membrane potential; regulation of oxidative phosphorylation; regulation of protein complex assembly; regulation of protein ubiquitination; response to oxidative stress; response to stress; ubiquitin-dependent protein catabolic process

Disease: Parkinson Disease 6, Autosomal Recessive Early-onset

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Product Notes

The Horse PINK1 pink1 (Catalog #AAA9363890) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9363890 ELISA Kit recognizes Horse PINK1. It is sometimes possible for the material contained within the vial of "Serine/Threonine-Protein Kinase PINK1, Mitochondrial (PINK1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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