Rat homer homolog 1 (Drosophila) ELISA Kit | HOMER1 elisa kit
Rat Homer protein homolog 1, HOMER1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds specifically to metabotropic glutamate receptor; may regulate metabotropic glutamate signaling [RGD, Feb 2006]
Uniprot Description
HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Contractile; Adaptor/scaffold; Cell adhesion; Cell development/differentiation
Cellular Component: neuron projection; costamere; dendrite; excitatory synapse; Z disc; postsynaptic membrane; cell soma; membrane; apical part of cell; axon; cytoplasm; plasma membrane; synapse; dendritic shaft; cell junction
Molecular Function: identical protein binding; protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffold; receptor binding
Biological Process: skeletal muscle contraction; response to nicotine; circadian rhythm; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor signaling pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport; response to cocaine
Research Articles on HOMER1
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Product Notes
The Rat HOMER1 homer1 (Catalog #AAA9332872) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332872 ELISA Kit recognizes Rat HOMER1. It is sometimes possible for the material contained within the vial of "homer homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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