Heterogeneous nuclear ribonucleoprotein L Recombinant Protein | HNRPL recombinant protein

Recombinant Human Heterogeneous nuclear ribonucleoprotein L

Cat. Num. AAA9420324

• Gene Names: HNRNPL; HNRPL; hnRNP-L; P/OKcl.14
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Heterogeneous nuclear ribonucleoprotein L; Recombinant Human Heterogeneous nuclear ribonucleoprotein L; HNRPL recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial, 89-335aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for HNRPL recombinant protein

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elents. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive elent (nCaRE) B2 of the APEX2 promoter.

NCBI and Uniprot Product Information

• NCBI GI #: 52632385
• NCBI GeneID: 3191
• NCBI Accession #: NP_001005335.1
• NCBI GenBank Nucleotide #: NM_001005335.1
• UniProt Accession #: P14866; Q9H3P3; A6ND69; A6NIT8
• Molecular Weight: 43.05kD
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein L isoform b
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein L
• NCBI Official Symbol: HNRNPL
• NCBI Official Synonym Symbols: HNRPL; hnRNP-L; P/OKcl.14
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein L
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein L
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPL
• UniProt Synonym Gene Names: HNRPL; hnRNP L

NCBI Description

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP L: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: membrane; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA metabolic process; RNA processing