Typical Testing Data/Standard Curve (for reference only)
Rat Hepatocyte nuclear factor 1-alpha ELISA Kit | Hnf1a elisa kit
Rat Hepatocyte nuclear factor 1-alpha ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
acts as a transcriptional activator; plays a role in the regulation of liver-specific genes [RGD, Feb 2006]
Uniprot Description
HNF1A: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF). Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3); also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20). IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Cellular Component: cytoplasm; nucleoplasm; nucleus; photoreceptor outer segment; pronucleus; protein complex; transcription factor complex
Molecular Function: DNA binding; double-stranded DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: bile acid and bile salt transport; bile acid biosynthetic process; blastocyst development; bone resorption; cholesterol metabolic process; chromatin remodeling; embryonic limb morphogenesis; endocrine pancreas development; fatty acid biosynthetic process; fatty acid transport; glucose homeostasis; glucose import; heme biosynthetic process; histone acetylation; insulin secretion; liver development; negative regulation of transcription from RNA polymerase II promoter; paraxial mesoderm formation; placenta development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein localization; regulation of hormone secretion; regulation of insulin secretion; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of Wnt receptor signaling pathway; reproductive structure development; response to glucose stimulus; response to oxidative stress; reverse cholesterol transport; transcription from RNA polymerase II promoter
Research Articles on Hnf1a
Similar Products
Product Notes
The Rat Hnf1a hnf1a (Catalog #AAA2884311) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884311 ELISA Kit recognizes Rat Hnf1a. It is sometimes possible for the material contained within the vial of "Hepatocyte nuclear factor 1-alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
