Histone H2B Recombinant Protein
Histone H2B (human), (recombinant)
Applications
Western Blot
Purity
>=95% (SDS-PAGE; Western blot)Purified by multi-step chromatography
Synonyms
Histone H2B; Histone H2B (human); (recombinant); Histone H2B recombinant protein
Host
E Coli
Purity/Purification
>=95% (SDS-PAGE; Western blot)
Purified by multi-step chromatography
Purified by multi-step chromatography
Form/Format
Liquid. In 1x Dulbecco's PBS
Applicable Applications for Histone H2B recombinant protein
Western Blot (WB), Kinase assay
Preparation and Storage
For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice
Shipping: Shipped on Dry Ice
Related Product Information for Histone H2B recombinant protein
The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The C-terminal domains of the core histones have very similar conformations that are important for nucleosome assembly. The N-terminal tails are less structured which is thought to allow for dynamic changes in the accessibility of the underlying genome. The N-terminal tail of core histones undergo different posttranscriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. Histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. histone H2B is phosphorylated in apoptotic cells and this event occurs around the time of nucleosomal DNA fragmentation. Phosphorylation of both histone H2A.X and H2B is dependant on caspase activation and therefore may be linked to caspase-induced signalling pathways.
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Product Notes
The Histone H2B (Catalog #AAA565897) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Histone H2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Kinase assay. Researchers should empirically determine the suitability of the Histone H2B for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Histone H2B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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