Human Hypoxia Inducible Factor 1, Alpha ELISA Kit | HIF-1alpha elisa kit
Human Hypoxia Inducible Factor 1, Alpha ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
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Product Notes
The Human HIF-1alpha hif1a (Catalog #AAA018031) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA018031 ELISA Kit recognizes Human HIF-1alpha. It is sometimes possible for the material contained within the vial of "Hypoxia Inducible Factor 1, Alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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