Human hairy and enhancer of split 6 (Drosophila) ELISA Kit | HES6 elisa kit
Human Transcription cofactor HES-6, HES6 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Uniprot Description
HES6: Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: transcription factor complex; nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription cofactor activity; transcription factor binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cell differentiation
Research Articles on HES6
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Product Notes
The Human HES6 hes6 (Catalog #AAA9329739) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329739 ELISA Kit recognizes Human HES6. It is sometimes possible for the material contained within the vial of "hairy and enhancer of split 6 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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