Mouse hect domain and RLD 2 ELISA Kit | HERC2 elisa kit
Mouse E3 ubiquitin-protein ligase HERC2, HERC2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HERC2: E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. Interacts (when phosphorylated at Thr-4827) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA.
Protein type: Ubiquitin conjugating system; EC 6.3.2.19; Mitochondrial; Ligase; EC 6.3.2.-; Ubiquitin ligase
Cellular Component: cytoskeleton; membrane; mitochondrial inner membrane; cytoplasm; nucleus
Molecular Function: SUMO binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; ubiquitin protein ligase binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; heme binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; spermatogenesis; DNA repair; response to DNA damage stimulus
Research Articles on HERC2
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Product Notes
The Mouse HERC2 herc2 (Catalog #AAA9339515) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339515 ELISA Kit recognizes Mouse HERC2. It is sometimes possible for the material contained within the vial of "hect domain and RLD 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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