Human hect domain and RLD 2 ELISA Kit | HERC2 elisa kit
Human E3 ubiquitin-protein ligase HERC2, HERC2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
Uniprot Description
HERC2: E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. Interacts (when phosphorylated at Thr-4827) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA.
Protein type: Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Mitochondrial
Chromosomal Location of Human Ortholog: 15q13
Cellular Component: centriole; membrane; mitochondrial inner membrane; cytoplasm; nucleus
Molecular Function: protein binding; SUMO binding; zinc ion binding; ubiquitin protein ligase binding; guanyl-nucleotide exchange factor activity; ubiquitin-protein ligase activity; heme binding; ligase activity
Biological Process: intracellular protein transport; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; spermatogenesis; DNA repair; response to DNA damage stimulus; positive regulation of GTPase activity
Disease: Prader-willi Syndrome; Mental Retardation, Autosomal Recessive 38; Skin/hair/eye Pigmentation, Variation In, 1
Research Articles on HERC2
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Product Notes
The Human HERC2 herc2 (Catalog #AAA9330543) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330543 ELISA Kit recognizes Human HERC2. It is sometimes possible for the material contained within the vial of "hect domain and RLD 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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