SDS-PAGE
(SDS-PAGE analysis of recombinant human soluble Ephrin-B2 produced in E. coli. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.)
FRP-1 active protein
Human FRP-1, soluble
SDS-PAGE
(SDS-PAGE analysis of recombinant human soluble Ephrin-B2 produced in E. coli. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.)
SDS-PAGE
(SDS-PAGE analysis of recombinant human soluble Ephrin-B2 produced in E. coli. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.)
NCBI and Uniprot Product Information
Uniprot Description
SFRP1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: cell surface; cytosol; extracellular matrix; extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane; proteinaceous extracellular matrix
Molecular Function: cysteine-type endopeptidase activity; drug binding; frizzled binding; G-protein coupled receptor activity; heparin binding; identical protein binding; protein binding; Wnt receptor activity; Wnt-protein binding
Biological Process: cellular response to starvation; dorsal/ventral axis specification; hemopoietic progenitor cell differentiation; menstrual cycle phase; negative regulation of apoptosis; negative regulation of B cell differentiation; negative regulation of bone remodeling; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of insulin secretion; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; osteoblast differentiation; positive regulation of apoptosis; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of epithelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of focal adhesion formation; positive regulation of GTPase activity; positive regulation of smoothened signaling pathway; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; regulation of angiogenesis; response to drug; response to organic cyclic substance; Wnt receptor signaling pathway through beta-catenin
Similar Products
Product Notes
The FRP-1 sfrp1 (Catalog #AAA692283) is an Active Protein produced from HeLa cells and is intended for research purposes only. The product is available for immediate purchase. The Human FRP-1, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMV LPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC L DRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIA MTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KI KEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCH QL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNH ECPTFQS VFK. It is sometimes possible for the material contained within the vial of "FRP-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
