FRP-1, soluble Active Protein | FRP-1 active protein
Human FRP-1, soluble
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Uniprot Description
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels
By similarity. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase
By similarity. In kidney development, inhibits tubule formation and bud growth in metanephroi
By similarity. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Subunit structure: Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8
By similarity. Ref.6
Subcellular location: Secreted. Note: Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Ref.2
Induction: Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Ref.3 Ref.7
Domain: The FZ domain is involved in binding with Wnt ligands
By similarity.
Miscellaneous: May have therapeutic use in cardiac surgery.
Sequence similarities: Belongs to the secreted frizzled-related protein (sFRP) family.Contains 1 FZ (frizzled) domain.Contains 1 NTR domain.
Mass spectrometry: Molecular mass is 7266.4 Da from positions 169 - 210. Determined by MALDI. Isoform N-glycosylatedon Asn-173. Ref.5
Research Articles on FRP-1
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Product Notes
The FRP-1 sfrp1 (Catalog #AAA691890) is an Active Protein produced from HeLa Cells and is intended for research purposes only. The product is available for immediate purchase. The Human FRP-1, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMV LPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC L DRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIA MTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KI KEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCH QL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNH ECPTFQS VFK. It is sometimes possible for the material contained within the vial of "FRP-1, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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