Macrophage Colony Stimulating Factor Active Protein | rM CSF active protein

Recombinant Rat Macrophage Colony Stimulating Factor

Cat. Num. AAA144744

• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Macrophage Colony Stimulating Factor; Recombinant Rat Macrophage Colony Stimulating Factor; M CSF Rat; Macrophage Colony Stimulating Factor Rat Recombinant; CSF-1; Lanimostim; MCSF; MGC31930; M-CSF; rM CSF active protein

• Host: HEK293
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The recombinant MCSF was lyophilized after extensive dialysis against PBS.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 566

• Solubility: It is recommended to reconstitute the MCSF in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of mouse M-NFS-60 cells.
• Preparation and Storage: Lyophilized MCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution MCSF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for rM CSF active protein

Description: MCSF Rat Recombinant produced in HEK-293 cells is a secreted protein (amino acids Glu33-Arg254). M-CSF is disulfide-linked homodimer containing 2 x 222 a.a chains.

Introduction: Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.

Product Categories/Family for rM CSF active protein

Cytokines and Growth Factors; Growth Factors; Colony Stimulating Factor

NCBI and Uniprot Product Information

• NCBI GI #: 28201782
• NCBI GeneID: 78965
• UniProt Accession #: Q8JZQ0
• Molecular Weight: 62,187 Da
• NCBI Official Full Name: Macrophage colony-stimulating factor 1
• NCBI Official Synonym Full Names: colony stimulating factor 1 (macrophage)
• NCBI Official Symbol: Csf1
• NCBI Protein Information: macrophage colony-stimulating factor 1; CSF-1; MCSF
• UniProt Protein Name: Macrophage colony-stimulating factor 1
• UniProt Gene Name: Csf1
• UniProt Synonym Gene Names: Csfm; CSF-1; MCSF
• UniProt Entry Name: CSF1_RAT

NCBI Description

plays a role in macrophage formation; involved in osteoclastogenesis and endochondral ossification [RGD, Feb 2006]

Uniprot Description

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance ().