SDS-Page
(Recombinant Human IL18R1/CD218a Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 80-105 kDa.)
IL18R1/CD218a Active Protein | IL18R1 active protein
Recombinant Human IL18R1/CD218a Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human IL18R1/CD218a Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 80-105 kDa.)
SDS-Page
(Recombinant Human IL18R1/CD218a Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 80-105 kDa.)
Background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Description
IL18R1: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding; receptor activity; interleukin-1 receptor activity; interleukin-18 receptor activity
Biological Process: positive regulation of interferon-gamma production; T-helper 1 cell differentiation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; immune response; signal transduction
Research Articles on IL18R1
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Product Notes
The IL18R1 il18r1 (Catalog #AAA9139694) is an Active Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ESCTSRPHIT VVEGEPFYLK HCSCSLAHEI ETTTKSWYKS SGSQEHVELN PRSSSRIALH DCVLEFWPVE LNDTGSYFFQ MKNYTQKWKL NVIRRNKHSC FTERQVTSKI VEVKKFFQIT CENSYYQTLV NSTSLYKNCK KLLLENNKNP TIKKNAEFED QGYYSCVHFL HHNGKLFNIT KTFNITIVED RSNIVPVLLG PKLNHVAVEL GKNVRLNCSA LLNEEDVIYW MFGEENGSDP NIHEEKEMRI MTPEGKWHAS KVLRIENIGE SNLNVLYNCT VASTGGTDTK SFILVRKADM ADIPGHVFTR. It is sometimes possible for the material contained within the vial of "IL18R1/CD218a, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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