CD27 Ligand/ CD70 Active Protein | CD70 active protein

Human CellExp CD27 Ligand/ CD70, Human Recombinant

Cat. Num. AAA8400005

• Gene Names: CD70; CD27L; CD27LG; TNFSF7
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD27 Ligand/ CD70; Human CellExp CD27 Ligand/ CD70; Human Recombinant; CD70; CD27LG; TNFSF7; TNFSF7G; CD27L; CD70 active protein

• Host: HEK293 cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Sequence: aaGln39-Pro193

• Gene Source: Human
• Endotoxin: Less than 1.0 EU per ug by the LAL method
• Biological Activity: Immobilized Human CD27, Fc Tag at 2 ug/mL (100 uL/well) can bind Human CD27 Ligand, His Tag with a linear range of 1-20 ng/mL
• Reconstitution Instruction: Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at store at -20 degree C.
• Tag Note: This protein carries a polyhistidine tag at the N-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Product Categories/Family for CD70 active protein

Proteins; Enzymes; Proteins & Enzymes (A-Z); Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); Cancer Research; Growth Factors; FGFs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4507605
• NCBI GeneID: 970
• NCBI Accession #: NP_001243.1
• NCBI GenBank Nucleotide #: NM_001252.3
• UniProt Accession #: P32970; Q96J57
• Molecular Weight: 21,118 Da
• NCBI Official Full Name: CD70 antigen
• NCBI Official Synonym Full Names: CD70 molecule
• NCBI Official Symbol: CD70
• NCBI Official Synonym Symbols: CD27L; CD27LG; TNFSF7
• NCBI Protein Information: CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7
• UniProt Protein Name: CD70 antigen
• Protein Family: CD70 antigen
• UniProt Gene Name: CD70
• UniProt Synonym Gene Names: CD27L; CD27LG; TNFSF7; CD27-L
• UniProt Entry Name: CD70_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Uniprot Description

CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction